Understanding cytokinesis interaction by interaction Structure Biology Diagrams

Understanding cytokinesis interaction by interaction Structure Biology Diagrams Animal cells, amoebas and yeast divide using a force-generating, actin- and myosin-based contractile ring or 'cytokinetic ring' (CR). Despite intensive research, questions remain about the spatial organization of CR components, the mechanism by which the CR generates force, and how other cellular processes are coordinated with the CR for successful membrane ingression and ultimate cell

Taking 400 pN for the fission yeast ring tension and 125 nm for the diameter of the actin bundle at the heart of the ring (Laplante et al. 2016), the ring generates a tensile stress of ~ 33 nN μm −2, similar to Rappaport's estimate of ~ 8 nN μm −2 in echinoderm eggs (Rappaport 1977), but 6 times smaller than the ~ 200 nN μm −2

Still and rotating myosin clusters determine cytokinetic ring ... Biology Diagrams

To analyse the formation of the pattern in the cytokinetic ring in mammalian cells, the intensity profiles were measured with ImageJ and a Fourier Transformation was performed with Matlab. We determined the cluster velocities in fission yeast rings as follows. Formation of the cytokinetic ring also requires IQGAP proteins, a family of proteins that have an IQ domain, a GTPase activation domain and an actin-binding calponin homology domain. The IQGAP protein Cyk1p/Iqg1p is required to recruit actin to the site of cytokinesis in response to signaling events .

I will use this review on the molecular mechanism of cytokinesis to highlight what we do not know. I focus on the contractile ring of actin filaments and myosin-II, which drives the formation of the cytokinetic furrow in animals, fungi, and amoebas. Nine questions, most posed 40 to 50 yr ago, remain unanswered or incompletely understood (Fig. 1

based control of the actin cytoskeleton during cytokinesis Biology Diagrams

ZipA and FtsA have partially overlapping roles in stimulating Z-ring formation in E. coli, but ZipA has a specific function in promoting pre-septal FtsZ-directed PG synthesis [50 A flexible C-terminal linker is required for proper FtsZ assembly in vitro and cytokinetic ring formation in vivo. Mol Microbiol (2013), 10.1111/mmi.12272. Google