Index of wwwscalable Biology Diagrams

Index of wwwscalable Biology Diagrams Defects of DNA-damage checkpoints, similar to impaired DNA-damage repair, promote genomic instability and predispose individuals to immunodeficiency, neurological defects, and cancer (Niida and Nakanishi, 2006). Although important advances have been made in understanding the cellular mechanisms behind the initiation and maintenance of

Connections between the DNA damage signaling kinases and DNA repair were scant at first, and the initial perception was that the importance of these kinases for genome integrity was largely an indirect effect of their roles in checkpoints, DNA replication, and transcription. As more substrates of DNA damage signaling kinases were identified, it

DNA damage checkpoint and repair: From the budding yeast Biology Diagrams

The effects of DNA damage include mutations, apoptosis, and more. This damage can lead to dysregulated cell function and eventually cancer, neurological disease, and premature aging. 2. Key Targets of DNA Damage Checkpoints. There are cell cycle checkpoints that can be activated in response to DNA damage. These DNA damage checkpoints include:

DNA repair and cell cycle checkpoint defects as drivers and therapeutic ... Biology Diagrams

A DNA damage checkpoint is a pause in the cell cycle that is induced in response to DNA damage to ensure that the damage is repaired before cell division resumes.

The fork in the road to DNA repair Biology Diagrams

DNA damage checkpoints and their reversal ... Biology Diagrams

The signal transducers activate p53 and inactivate cyclin-dependent kinases to inhibit cell cycle progression from G1 to S (the G1/S checkpoint), DNA replication (the intra-S checkpoint), or G2 to mitosis (the G2/M checkpoint). In this review the molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed.

Figure 1 from Orchestration of DNA Damage Checkpoint Dynamics across ... Biology Diagrams

ABSTRACT. Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells must detect the break and either transiently block cell cycle progression, to allow time for repair, or exit the cell cycle. Reversal of a DNA-damage-induced checkpoint not only requires the repair of these

The G 2 DNA damage checkpoint signaling pathway. (A) DNA damage, repair ... Biology Diagrams